Publications
PAK Publications
Fully integrated downstream process to enable next-generation manufacturing
Abstract Next‐generation manufacturing (NGM) has evolved over the past decade to a point where large biopharmaceutical organizations are making large…
Read MoreRelevant Publications
Current challenges and recent advances on the path towards continuous biomanufacturing
Abstract Continuous biopharmaceutical manufacturing is currently a field of intense research due to its potential to make the entire production…
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Integrated continuous biomanufacturing on pilot scale for acid‐sensitive monoclonal antibodies
Abstract In this study, we demonstrated the first, to our knowledge, integrated continuous bioprocess (ICB) designed for the production of…
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End-to-end collaboration to transform biopharmaceutical development and manufacturing
Abstract An ambitious 10‐year collaborative program is described to invent, design, demonstrate, and support commercialization of integrated biopharmaceutical manufacturing technology…
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Continuous downstream processing for biomanufacturing: an industry review
Abstract BioPhorum’s First Edition Technology Roadmap outlines a ten-year vision for therapeutic protein production in the biopharmaceutical industry. This paper…
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Multistage continuous countercurrent diafiltration for formulation of monoclonal antibodies
Abstract There is growing interest in the development of fully integrated and continuous biomanufacturing processes for the production of monoclonal…
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Single pass diafiltration integrated into a fully continuous mAb purification process
Abstract The concept of continuous manufacturing has gained significant interest from the biopharmaceutical industry over the past several years. Benefits…
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09.23.2026Lowering mAb Cost per Gram: The Economics of a mAb Facility with 4x Higher Output
Increase manufacturing productivity, reduce your cost per gram. If a commercial mAb facility can produce four times more product without a proportional increase in costs, the economics of manufacturing change dramatically.
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08.11.2026PAK BioSolutions and Cytiva Demonstrate Integrated Continuous Downstream Processing
Vienna, VA — August 11, 2026 — PAK BioSolutions is proud to highlight its collaboration with Cytiva to advance process…
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07.02.2026Major Biopharmaceutical Company Files First-in-Human Trial Supported by PAK BioSolutions GMP Purification System
Vienna, VA — July 2, 2026 — PAK BioSolutions today announced that a major biopharmaceutical company has successfully filed a…
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06.17.2024PAK BioSolutions Raises $12 Million Series A to Expand Continuous Biomanufacturing Product Line
Vienna, VA: Today, PAK BioSolutions announced that it has raised $12M from Arboretum Ventures, BroadOak Capital Partners, and other investors…
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04.10.2024PAK BioSolutions Named Top Employer for Interns, 2024
Vienna, VA – PAK BioSolutions was named a Top Employer for Interns today by the Virginia Chamber of Commerce. The…
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11.14.2023Employee Highlight: C.J. Hall
C.J. Hall is an Engineer at PAK BioSolutions, where he specializes in sourcing, R&D, and system operation. This past fall,…
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09.21.2023PAK BioSolutions Enters Video Competition
Vienna, VA – PAK BioSolutions has entered the BioTools Innovator Best Video Competition. There are 17 entries this year, and…
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09.05.2023How Industrial-Organizational Psychology Informs Working Conditions
We owe basic worker’s rights and safe working conditions to the American Labor Movement, which we celebrate with Labor Day…
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09.01.2023PAK BioSolutions Named Top Virginia Employer for Interns
Vienna, VA – PAK BioSolutions has been given the 2023 Top Virginia Employers for Interns Award by the Virginia Talent…
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07.31.2023The State of Sustainability in 2023
Sustainability went mainstream for businesses back in 2021, according to the Harvard Business Review. To get on track for goals…
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07.26.2023
Current challenges and recent advances on the path towards continuous biomanufacturing
Abstract Continuous biopharmaceutical manufacturing is currently a field of intense research due to its potential to make the entire production…
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07.15.2023
Employee Highlight: Huda Khawar
Huda Khawar is a Laboratory Technician at PAK BioSolutions. As a Lab Technician, she is responsible for the assembly of…
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07.13.2023Interview with Summer Interns
This summer, PAK BioSolutions welcomed two undergraduate interns into the office. Julia Feldhaus is an upcoming third year at University…
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06.15.2023
BioTools Innovator Chooses PAK BioSolutions as Finalist
Vienna, VA – PAK BioSolutions has been chosen as a finalist for the Biotools Innovator 2023 program. This program serves…
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06.01.2023PAK BioSolutions Offers Training Course
Vienna, VA – PAK BioSolutions, Inc. has announced a Continuous Purification Course to take place the week of August 28-September…
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05.02.2023Employee Highlight: Kevin Hill-Byrne
Kevin Hill-Byrne is the Co-Founder and CTO of PAK BioSolutions. As CTO, he is responsible for overseeing new product development…
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04.18.2023PAK BioSolutions Wins Biotech Innovation Award
Vienna, VA – PAK BioSolutions has been awarded the Biotech Innovation Award for INTERPHEX 2023. The show, taking place April…
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03.23.2023New Publication in Biotechnology and Bioengineering
Vienna, VA – In cooperation with AstraZeneca, PAK BioSolutions has published a new article in the latest issue of Biotechnology…
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03.12.2023
Fully integrated downstream process to enable next-generation manufacturing
Abstract Next‐generation manufacturing (NGM) has evolved over the past decade to a point where large biopharmaceutical organizations are making large…
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08.08.2022PAK BioSolutions Announces Grant from NCATS, FDA, CDC
Vienna, VA – PAK BioSolutions, Inc. (PAK BioSolutions or the Company), a biotechnology company developing products for the continuous purification…
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04.23.2022
Integrated continuous biomanufacturing on pilot scale for acid‐sensitive monoclonal antibodies
Abstract In this study, we demonstrated the first, to our knowledge, integrated continuous bioprocess (ICB) designed for the production of…
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04.06.2021Patent Granted for PAK Flow Kit
Fairfax, VA – PAK BioSolutions has been awarded its first patent for a “Therapeutic Protein Flow Kit for a Continuous…
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01.18.2021
End-to-end collaboration to transform biopharmaceutical development and manufacturing
Abstract An ambitious 10‐year collaborative program is described to invent, design, demonstrate, and support commercialization of integrated biopharmaceutical manufacturing technology…
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01.06.2021Continuous Processes Reduce Equipment Size and Cost
How does a PAK BioSolutions purification suite revolutionize the manufacture of pharmaceuticals? With a correctly-designed continuous purification process, a PAK…
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01.05.2021
Reduce Consumable Expenses with Continuous Purification
Significant cost savings are commonly advertised for continuous biopharmaceutical processes, but where they come from is not always immediately apparent….
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01.04.2021Productivity – What is it and how do we improve it?
What exactly is productivity? At PAK BioSolutions, we define productivity for a biopharmaceutical process, whether batch or continuous, as the…
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10.08.2020PAK BioSolutions Featured in GEN News
Fairfax, VA – PAK BioSolutions Inc. was featured in the latest edition of Genetic Engineering & Biotechnology News (GEN). The…
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06.19.2020First PAK System Delivered to HQ
Fairfax, VA – PAK BioSolutions, Inc. received its first automated system for continuous purification of biopharmaceuticals from the automation integrators…
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06.12.2019Continuous downstream processing for biomanufacturing: an industry review
Abstract BioPhorum’s First Edition Technology Roadmap outlines a ten-year vision for therapeutic protein production in the biopharmaceutical industry. This paper…
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03.20.2019
Multistage continuous countercurrent diafiltration for formulation of monoclonal antibodies
Abstract There is growing interest in the development of fully integrated and continuous biomanufacturing processes for the production of monoclonal…
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01.31.2019
PAK BioSolutions Submits Patent Application for Solid, Single Use Flow Kit
Alexandria, VA – A patent application has been submitted for a solid, single use flow kit designed for purification of…
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10.05.2018
PAK BioSolutions Founded
Fairfax, VA – PAK BioSolutions, Inc. was recently founded and today welcomes on board Vice-President and co-founder Kevin Hill-Byrne. The…
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04.06.2018
Single pass diafiltration integrated into a fully continuous mAb purification process
Abstract The concept of continuous manufacturing has gained significant interest from the biopharmaceutical industry over the past several years. Benefits…
